Nonprescription agents have also been used for treatment of onychomycosis ( Table 4 ) . 31 , 33 – 38 These therapies have been evaluated in only a small number of studies involving few patients. Topical mentholated ointment (Vicks Vaporub) was used in a small study involving 18 patients. 37 After 48 weeks, 28% had mycotic and clinical cure, 56% had partial clearance, and 17% had no improvement. Tea tree oil ( Melaleuca alternifolia ) has been evaluated in two studies. Although one trial was favorable, combined data from both studies did not demonstrate significant benefit. 29 , 36 Snakeroot extract ( Ageratina pichinchensis ) is an antifungal derived from plants of the sunflower family. It was studied in a randomized trial involving 96 patients who applied the extract or ciclopirox for six months to nails with confirmed infections. 33 Mycotic cure occurred in 59% of patients receiving the extract and in 64% of those receiving ciclopirox. Clinical cure occurred in 71% and 81% of patients, respectively. Differences between the two treatments were not statistically significant. A small study showed that a combination of cyanoacrylate, undecylenic acid, and hydroquinone (marketed as Renewed Nail) demonstrated mycotic cure in 78 of 154 participants (50%). 34
Fungi will often cause the area around the nail to become red and irritated. Initially a fungus will take hold at the base or edges of the nail. Once the infection continues to spread you'll notice changes in your nail and nail bed. You may experience mild discomfort, itching, or perhaps even sharp pain around the cuticle which is the skin surrounding the nail. Bleeding may begin to occur and often detachment from the cuticle to the nail may result. The nail will begin a slow transformation to perhaps a yellow, brown, or white coloration. Nails will often become thicker and extremely brittle. You may experience discomfort when you put weight on any fungal infected nail.
Ingredients : De-ionized Water, Aloe Vera (Aloe barbadensis) Leaf Gel*, Emulsifying Wax, Avocado Oil (Persea gratissima), Vegetable Glycerin, Stearic Acid (vegetable source), Natural Progesterone (USP Grade), Phospholipids (from Soy Lecithin), Glucose/Glucose Oxidase/Lactoperoxidase (natural preservative), Balancing Herbal Blend of: Rosemary Leaf Extract (Rosmarinus officinalis), Grapefruit Seed Extract (Citrus grandis), Carrot Oil (Daucua carota sativa), Sarsaparilla Root Extract (Smilax officinalis syn. S. regelii), Dong Quai Root Extract (Angelica polymorpha var. sinensis), Saw Palmetto Extract (Serenoa serrulata Fruit Extract), Chamomile Flower Extract (Matricaria recutita), Lemongrass Oil (Cymbopogon citratus) and Comfrey Root Extract (Symphytum officinale), Triethanolamine, Carbomer, Natural Vitamin E (as d-alpha-Tocopherol), Potassium Sorbate, Panthenol, Vitamin A (as Retinyl Palmitate), Citric Acid and Xanthan Gum (Xanthomonas campestris). *Certified Organic