I can’t really comment without knowing your numbers or how much T you’re on. But Arimidex is a pretty strong drug. I used to take .25 a couple times a week and it tanked me. Depression, loss of just about everything, mood swings you name it. (Thing is, I didn’t even realize I was low until after I finally managed to control things. Looking back now I don’t know how I made it through to be honest) These days I take 1/8th a cut from a 1mg pill perhaps every two weeks. But what made a big difference for me (and I was really resistant to trying this) was splitting my dose and taking it twice a week. (So if you’re on 1ml a week do .5ml every 3-4 days) I know it seems like it wouldn’t help much, but it does. The idea behind this is that your T levels never spike high enough to convert over to Estrogen. I highly suggest it. Since doing so, I rarely have to take Arimidex to correct my estrogen levels. It took about 2 weeks but my drive, energy, thought process everything is what I would consider back to normal if not better than pre TRT.