Testosterone inhibitor

10. Sleep and Fatigue . Inadequate testosterone can also lead to poor sleep quality, which means that the only thing you'll want to do under the covers is put your head on the pillow and crash.  Testosteorne deficiencies decrease the all-important recuperative REM sleep and other critical sleep parameters. One study showed that low T did this not only by increasing weight gain, which negatively impacts sleep in and of itself, but also through other mechanisms that we do not yet understand. [11] And none of this should be a surprise considering how much that testosterone affects the brain.

Because of its anabolic effects on muscle, testosterone is being explored as a function-promoting anabolic therapy for functional limitations associated with aging; however, concerns about testosterone's adverse effects on prostate have inspired efforts to develop strategies that selectively increase muscle mass while sparing the prostate. Testosterone's promyogenic effects are mediated through upregulation of follistatin. We show here that the administration of recombinant follistatin (rFst) increased muscle mass in mice, but had no effect on prostate mass. Consistent with the results of rFst administration, follistatin transgenic mice with constitutively elevated follistatin levels displayed greater muscle mass than controls, but had similar prostate weights. To elucidate signaling pathways regulated differentially by testosterone and rFst in prostate and muscle, we performed microarray analysis of mRNAs from prostate and levator ani of castrated male mice treated with vehicle, testosterone, or rFst. Testosterone and rFst shared the regulation of many transcripts in levator ani; however, in prostate, 593 transcripts in several growth-promoting pathways were differentially expressed after testosterone treatment, while rFst showed a negligible effect with only 9 transcripts differentially expressed. Among pathways that were differentially responsive to testosterone in prostate, we identified ornithine decarboxylase (Odc1), an enzyme in polyamine biosynthesis, as a testosterone-responsive gene that is unresponsive to rFst. Accordingly, we administered testosterone with and without α-difluoromethylornithine (DFMO), an Odc1 inhibitor, to castrated mice. DFMO selectively blocked testosterone's effects on prostate, but did not affect testosterone's anabolic effects on muscle. Co-administration of testosterone and Odc1 inhibitor presents a novel therapeutic strategy for prostate-sparing anabolic therapy.

Dutasteride (Avodart) has more complete suppression of all three 5α-reductase isoenzymes. It inhibits types 1 and 2 better than finasteride, leading to it causing further reduction in DHT at 6 months than the older drug (% versus %). [27] It also reduces intraprostatic DHT 97% in men with prostate cancer at 5 milligrams per day over three months. [28] A second study with  mg/d for 4 months decreased intraprostatic DHT even further by 99%. [29] It has also been shown to inhibit the 5α-R3 isoenzyme in vitro , [30] suggesting that dutasteride may be a triple 5α reductase inhibitor in vivo . [16]

Test HD is the first hardcore testosterone booster to include a clinical-strength dose of shilajit, a rare organo-mineral compound obtained from steep rocks of different formations found in the Himalayas and other high mountains. Shilajit in its natural state has no chemical definition. In order to yield a consistent and efficacious form of shilajit, the shilajit is obtained from carefully selected rocks and is put through a patented technology where it is purified and standardized. This form of shilajit is now assured of optimal levels of bioactive components such as fulvic acid and dibenzo-pyrones, and is known as the patented PrimaVie.

Testosterone inhibitor

testosterone inhibitor

Test HD is the first hardcore testosterone booster to include a clinical-strength dose of shilajit, a rare organo-mineral compound obtained from steep rocks of different formations found in the Himalayas and other high mountains. Shilajit in its natural state has no chemical definition. In order to yield a consistent and efficacious form of shilajit, the shilajit is obtained from carefully selected rocks and is put through a patented technology where it is purified and standardized. This form of shilajit is now assured of optimal levels of bioactive components such as fulvic acid and dibenzo-pyrones, and is known as the patented PrimaVie.

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