In males with delayed puberty: Various dosage regimens have been used; some call for lower dosages initially with gradual increases as puberty progresses, with or without a decrease to maintenance levels. Other regimens call for higher dosage to induce pubertal changes and lower dosage for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose. Dosage is within the range of 50 to 200 mg every 2 to 4 weeks for a limited duration, for example, 4 to 6 months. X-rays should be taken at appropriate intervals to determine the amount of bone maturation and skeletal development (see INDICATIONS AND USAGE and WARNINGS ).
For the purpose of understanding and profiling phenylpropionate we will discuss its characteristics as an individual API. Phenylpropionate on its own usually gets administered twice a week or every third day. It has the usual side effects as all other testosterones. It has a high level of aromatization into estrogen and converts to DHT (dihydrotestosterone) as well. Conversion to estrogen creates as per usual gynecomastia and water retention. Water retention and an increase in blood pressure are also expected. Natural HPTA axis shuts down as soon as it gets administered and natural production of testosterone stops. The severity of the side effects is usually dose related and the higher the dose the more the side effects.
The preservative benzyl alcohol has been associated with serious adverse events, including the "gasping syndrome", and death in pediatric patients. Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys’ capacity to detoxify the chemical. Premature and low-birth weight infants may be more likely to develop toxicity.