Severe renal impairment can alter exenatide pharmacokinetic parameters and lead to accumulation of the drug due to reduced clearance. Exenatide should not be used in patients with severe renal impairment (CrCl < 30 mL/min) or end-stage renal disease (ESRD) or renal failure; it should be used with caution in patients with a kidney transplant and in patients with CrCl 30—50 mL/min. Among patients with end-stage renal disease receiving dialysis, the mean exenatide exposure increased by -fold as compared with values obtained from patients with normal renal function. In patients with ESRD receiving dialysis, single 5 mcg doses of exenatide were poorly tolerated due to gastrointestinal side effects (nausea, vomiting, diarrhea). Nausea and vomiting may cause transient hypovolemia, which may worsen renal function.
Anabolic steroid implants are allowed for veterinary use. But if someone diverts this for use in humans, it will be deemed as a distribution of a Schedule III drug leading to prosecution. The law on trenbolone differs in other countries. For instance, in Canada it is a Schedule IV drug. In Canada, all anabolic steroids are classified as Schedule IV drugs. In the UK, anabolic steroids are classified as Class C substances. Their possession can lead to a 2 year jail term, while their production and supply can lead to a 14 year jail term. But many countries do not have strict laws. In some places, you can even buy it over the counter.