Nandrolone decanoate (Deca-Durabolin) was injected intramuscularly into healthy volunteers. One group of females received one injection of 100 mg and three groups of males received one injection of 200 mg, two repeat injections of 100 mg or four repeat injections of 50 mg respectively. The serum levels of nandrolone (19-nortestosterone) were determined by radioimmunoassay and used to estimate pharmacokinetic parameters. The following pharmacokinetic parameters were found: a mean half-life of 6 days for the release of the ester from the muscular injection depot into the general circulation; a mean half-life of h for the combined processes of hydrolysis of nandrolone decanoate and of distribution and elimination of nandrolone; a mean nandrolone serum clearance of 1 X h-1 X kg-1. The half-life of hydrolysis of nandrolone decanoate in serum was of the order of one hour or less. The data are consistent with linear kinetics.
Around fifth part of the injected steroid binds to progestin receptors (due to the absence of a carbon atom in the 19 position), and therefore, such reactions as the suppression of secretion of gonadotropin-releasing hormone, increased production of prolactin, a significant decrease in libido should not be excluded. Weak erection - the most pronounced and severe consequence of abuse of deca nandrolone. Exceeding of the recommended dosage and duration of the course may cause rhinitis, headache, back pain, rash. In general, the side effects of nortestosterone decanoate - rather the exception than the rule.
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