Intraocular pressure, glaucoma
Have you heard of DHEA causing high IOP (intraocular pressure) or possibly temporary glaucoma. I have been taking DHEA for about a year. I like the benefits it has provided both physically and mentally. However my last flight physical for the military showed me having high IOP in both eyes. Two days after I stopped taking DHEA my pressures where back to normal.
I have not heard of this side effect yet, and I have not seen it mentioned in the medical literature, however it is a possibility to consider. There's a lot we don't know about the long term effects of DHEA. If your IOP is increased again after restarting the DHEA and then returns to normal after stopping, then that would make it quite likely that in your case it was involved.
Although research on the safety of long-term or regular use of DHEA is currently lacking, there's some concern that it may alter liver function, interfere with cholesterol control, affect hormone levels (such as insulin, thyroid hormones, and adrenal hormones), and increase the risk of blood clots. Therefore, people with liver disease, diabetes, high cholesterol, thyroid disorders, blood clotting disorders, hormonal disorders, or hormone-sensitive conditions (such as breast cancer and prostate cancer) should take caution when using DHEA. Those with a history of heart disease or stroke should avoid DHEA supplements.
Uses based on scientific studies:
ADRENAL INSUFFICIENCY: Several studies show DHEA may improve well-being, quality of life, exercise capacity, sex drive and hormone levels in people with insufficient adrenal gland function. Raising DHEA levels in persons with partial androgen deficiency seems to benefit the age related decline in the mental and physical functions.
The majority of clinical trails investigating the effect of DHEA on Depression, Obesity, Systemic lupus erythematosus and Rheumatoid arthritis support its use for these purposes.
DHEA is under investigation for benefiting bone density, cervical cancer, chronic fatigue syndrome, menopausal disorders, HIV/AIDS, sexual function, immune system stimulant and skin aging.