Dhea effects on testosterone

7-Keto-DHEA (also called 7-Keto) has applications for bodybuilding, strength athletes and general fitness enthusiasts. This naturally occurring metabolite offers many benefits without side effects. Although not fully researched yet, tests have shown its positive effects can be far reaching. This product is a metabolite of dehydroepiandrosterone or DHEA, a hormone produced naturally in the body. DHEA is manufactured from the adrenal glands near the kidneys. The sheer volume of DHEA produced by these glands far exceeds any other hormones produced in the body.

Correlations between circulating DHEA/DHEAS levels and urticaria and other immune-related disorders has led to proposals for DHEA supplementation. However, clinical trials are largely lacking. 28 , 29 , 30 In 1 study, no effect of DHEA supplementation was found in well-established rheumatoid arthritis. 24 Decreased disease activity was observed in a study of patients with inflammatory bowel disease. However, the study was not placebo controlled. 24 Animal studies of experimental sepsis and trauma have shown DHEA to decrease splenocyte proliferation and increase circulating NK cells and CD8+ lymphocytes; a role in managing critical illness has been suggested as a result. 31

Life Extension Foundations recommendations for DHEA supplementation for women are not based on resources, research, and references with sound science evidence based information. Instead of DHEA, women should supplement with pregnenolone, which is the mother of all hormones. Women should not supplement with DHEA which is androgenic in women and causes masculine characteristics -especially if menopausal women are not on Hormone Replacement Therapy (see resources, research and references with sound science evidence noted here in this reply section.) Women who are in menopause should be on hormone replacement therapy with real estradiol in a transdermal patch and micronized progesterone inserted vaginally and both cycled in a monthly fashion as sex hormones are neurosteroids necessary for brain health, activate stem cells for cell regeneration, activate serotonin and dopamine neurons, activate the p53 tumor suppressor gene and inhibit mTOR which synthetic estrogen, estrone, conjugated equine estrogen and synthetic progesterone do not.

Because there is no guarantee of strength, purity or safety of DHEA products (they are not usually regulated by the Food and Drug Administration), it’s important to read labels, do your research when buying supplements and follow directions. ( 11 ) The University of Maryland Medical Center advises that you try to purchase DHEA directly from a doctor in order to ensure it’s authentic and not contaminated. DHEA comes in capsule, tablet, chewing gum, sublingual (under the tongue) drop and topical (on the skin) cream form, but the type you’ll want to use depends on what you’re using it for. ( 12 )

Intraocular pressure, glaucoma
Have you heard of DHEA causing high IOP (intraocular pressure) or possibly temporary glaucoma. I have been taking DHEA for about a year. I like the benefits it has provided both physically and mentally. However my last flight physical for the military showed me having high IOP in both eyes. Two days after I stopped taking DHEA my pressures where back to normal.
   I have not heard of this side effect yet, and I have not seen it mentioned in the medical literature, however it is a possibility to consider. There's a lot we don't know about the long term effects of DHEA. If your IOP is increased again after restarting the DHEA and then returns to normal after stopping, then that would make it quite likely that in your case it was involved.

Dhea effects on testosterone

dhea effects on testosterone

Because there is no guarantee of strength, purity or safety of DHEA products (they are not usually regulated by the Food and Drug Administration), it’s important to read labels, do your research when buying supplements and follow directions. ( 11 ) The University of Maryland Medical Center advises that you try to purchase DHEA directly from a doctor in order to ensure it’s authentic and not contaminated. DHEA comes in capsule, tablet, chewing gum, sublingual (under the tongue) drop and topical (on the skin) cream form, but the type you’ll want to use depends on what you’re using it for. ( 12 )

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